Usan la Teoría de Redes Complejas con enfermedades cerebrales

Ciertos libros parecen haber sido escritos no para aprender de ellos, sino para que se reconozca lo que sabía su autor

Goethe

Un equipo de once investigadores del Centro de Tecnología Biomédica de la Universidad Politécnica de Madrid, formado por médicos, neuropsicólogos, ingenieros, físicos y matemáticos, intenta comprender, desde un nuevo punto de vista, cómo el deterioro cognitivo leve (DCL) influye en la compleja red de interacciones entre diferentes zonas cerebrales.

El trabajo parte de medidas de la actividad cerebral de un grupo de pacientes con DCL mediante magnetoencefalografía. Esta técnica permite medir con una alta resolución temporal el campo magnético generado por millones de neuronas situadas en la zona cortical del cerebro. Concretamente, se estudió dicha actividad durante una tarea de memoria. Seguidamente se realizó el mismo experimento con sujetos sanos.

Método
La principal novedad del trabajo radica en el método de análisis de las mediciones experimentales. Se obtuvieron las redes funcionales cerebrales de todos los sujetos con el cálculo de la sincronización entre las zonas cerebrales. Los nodos de la red se correspondían con las diferentes zonas de la corteza cerebral, y las conexiones entre ellas dependían de la forma e intensidad en que estaba sincronizada la actividad electromagnética.

Una vez obtenida la red compleja, su análisis topológico -matemático- reveló resultados muy interesantes, como que diferentes parámetros de red -camino medio, clustering, alcance- permitían diferenciar entre los sujetos de ambos grupos y detectar qué individuos habían desarrollado la enfermedad y cuáles no.

Los resultados del proyecto, publicado en PLoS One, han sido seleccionados por Nature Reviews Neurology como uno de los trabajos más interesantes del último mes.

Fuente:www.diariomedico.com

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