Los sistemas requieren complejidad de tecnologías

La ignorancia es la noche de la mente, pero una noche sin luna ni estrellas

Confucio

Mario R. Capecchi, profesor de la Facultad de Medicina de la Universidad de Utah, en Salt Lake City, e investigador del Instituto Médico Howard Hughes, en New Haven, en el mismo estado norteamericano, fue distinguido con el premio Nobel de Fisiología y Medicina en 2007 -compartido con Oliver Smithies y Martin Evans- por el desarrollo de la metodología gene targeting en células derivadas de embriones de ratón, la cual tiene grandes implicaciones en la investigación biomédica. De hecho, su manejo permite a los investigadores conseguir ratones con mutaciones en cualquier gen de interés y estudiar con detalle su función durante el desarrollo o en fases posteriores de la vida del animal, la progresión de un modelo de enfermedad humana inducida y el ensayo de terapias.

Según Capecchi, galardonado con uno de los Premios Cátedra Santiago Grisolía 2011, adscrita a la Fundación Ciudad de las Artes y las Ciencias, estos avances son metodológicos y tecnológicos y obedecen a la propia complejidad del campo biomédico. “Estamos conociendo la complejidad de los sistemas -especialmente la del sistema nervioso- y ello requiere también una complejidad de tecnologías.

De esta manera tendremos más variables y podremos manipular de manera específica para conseguir una respuesta razonable”, ha señalado durante una de sus lecciones magistrales del curso Gene targeting en el siglo XXI. Generación de modelos de enfermedades humanas: del cáncer a los trastornos neuropsiquiátricos. “Necesitamos estas herramientas para abordar las preguntas con mucho sentido que queremos afrontar”, y ha remarcado que “lo bueno del ratón o de la rata es que podemos hacer literalmente lo que queramos manipulando su ADN y, aunque posteriormente no se puedan realizar muchas operaciones, lo que podemos hacer es algo muy sofisticado”. Actualmente, la investigación de Capecchi se dirige, entre otros aspectos, a la producción de modelos en ratón de enfermedades genéticas humanas, la terapia génica y el reordenamiento programado del genoma del ratón.

En este escenario, ha destacado que los avances o apuestas interesantes “son de alto riesgo” y, en ocasiones, “requieren el desarrollo de una tecnología que no existe”. A modo de ejemplo, “quiero poder mover megabases, pero no existe la tecnología y, por tanto, se trata de un problema muy difícil. No obstante, hay que seguir intentándolo y, una vez que podamos hacerlo, se abrirán nuevas puertas que habrá que franquear”. Además, ha señalado que la evolución del gene targeting depende, entre otros aspectos, de “trabajar con varios genes a la vez y desencadenarlos en distintos tejidos de manera independiente para ver sus interacciones”. Asimismo, ha hecho hincapié en la necesidad de mejorar los aspectos tecnológicos para abarcar un aspecto clave: comprender realmente como está funcionando nuestro cerebro en tiempo real.

Ratones y ratas
Aunque el gene targeting se ha realizado esencialmente hasta la fecha en ratones, Capecchi ha destacado que también comienza a estar disponible y a trabajarse en ratas. No obstante, “la rata no va a sustituir al ratón” y a ello contribuyen aspectos como el mayor coste que, debido a su superior tamaño, supone criar y trabajar con los primeros.

Además, ha apuntado que otra diferencia fundamental se asocia con el concepto de endogamia: “La mayoría de las líneas de ratas no tienen endogamia, mientras que un ratón genera 20 generaciones o más y se produce esa endogamia, lo que supone que sus antecedentes genéticos sean uniformes”. Según Capecchi, podrán realizarse estudios específicos para ratas, aunque se ha mostrado bastante escéptico respecto a que se basen en el concepto o la idea de que es más inteligente que el ratón.

Fuente:www.diariomedico.com

99 Responses to “Los sistemas requieren complejidad de tecnologías”

  1. Anonymous says:

    same day payday loan…

    In addition to raising Pell Grants, the check provides $1…

  2. Anonymous says:

    payday loans…

    In addition, the more you can put down, the cheaper you have to inquire and the easier it will be to get the personal loan in the first place…

  3. Anonymous says:

    online casino…

    Scan them like had to wager Ten thousand dollars to Induce the bonus Redeemable!…

  4. Anonymous says:

    payday loans…

    You will as a result have to make certain you do not fall into such a entice as this…

  5. Anonymous says:

    poker sites uk…

    Among the entropy you’ll chance on the website are halting patterns for various descriptors of poker, first in legitimizing online poker rooms in the United States….

  6. Anonymous says:

    betting online…

    We are recommending a substantiation email you can log into your News report and spiel your 5 Rid Casino Chips!…

  7. Anonymous says:

    internet casinos…

    betting is opened Monday through listed on the New York fund substitution Big board with a farsighted account in the amusement and gambling industries….

  8. Websites you should visit…

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose…

  9. google.com says:

    Excellent website…

    the time to read or visit the content or sites we have linked to below the…

  10. Sources…

    Here are some of the sites we recommend for our visitor…

  11. Great website…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  12. Cool sites…

    Here are some of the sites we recommend for our visitor…

  13. Blogs you should be reading…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  14. Online Article…

    Every once in a while we choose blogs that we read. Listed above are the latest sites that we choose…

  15. Blogs you should be reading…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  16. Excellent website…

    the time to read or visit the content or sites we have linked to below the…

  17. So cool…

    The information provided in the article are some of the best available…

  18. Cool sites…

    Here are some of the sites we recommend for our visitor…

  19. SITE LINK says:

    Check this out…

    The information mentioned in the article are some of the best available…

  20. Great website…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  21. Websites you should visit…

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose…

  22. Great website…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  23. locksmith says:

    Cool sites…

    Here are some of the sites we recommend for our visitor…

  24. Websites you should visit…

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose…

  25. coupon october 2013…

    He can compress the most words into the smallest ideas of any man I ever met….

  26. So cool…

    The information mentioned in the article are some of the best available…

  27. Online Article…

    Every so often in a while we choose blogs that we read. Listed underneath are the latest sites that we choose…

  28. more info says:

    Websites we think you should visit…

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out…

  29. Sources…

    Here are some of the sites we recommend for our visitor…

  30. Link says:

    Great website…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  31. Check this out…

    The information mentioned in the article are some of the best available…

  32. Myla Sinanj says:

    Great Content…

    we like to honor many other web sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out…

  33. Excellent website…

    the time to read or visit the content or sites we have linked to below the…

  34. Blogs you should be reading…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  35. Online Article…

    Every so often in a while we choose blogs that we read. Listed underneath are the latest sites that we choose…

  36. Blogs you should be reading…

    please visit the sites we follow, including this one, as it represents our picks from the web…

  37. Kim K says:

    Cool sites…

    Here are some of the sites we recommend for our visitor…

  38. Online Article…

    Every so often in a while we choose blogs that we read. Listed underneath are the latest sites that we choose…

  39. Websites you should visit

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose

  40. So cool

    The information mentioned in the article are some of the best available

  41. Sites we like

    the time to read or visit the content or sites we have linked to below the

  42. Great Content

    we like to honor many different web sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  43. So cool

    The information mentioned in the article are some of the best available

  44. Sites we like

    the time to read or visit the content or sites we have linked to below the

  45. Online Article

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose

  46. Websites we think you should visit

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  47. click here says:

    Sources

    Here are some of the sites we recommend for our visitor

  48. Kim K says:

    Cool sites

    Here are some of the sites we recommend for our visitor

  49. Cool sites

    Here are some of the sites we recommend for our visitor

  50. Great website

    please visit the sites we follow, including this one, as it represents our picks from the web

  51. So cool

    The information provided in the article are some of the best available

  52. Sites we like

    the time to read or visit the content or sites we have linked to below the

  53. Online Article

    Every so often in a while we choose blogs that we read. Listed above are the latest sites that we choose

  54. Sources

    Here are some of the sites we recommend for our visitor

  55. Cool sites

    Here are some of the sites we recommend for our visitor

  56. Websites we think you should visit

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  57. Cool sites

    Here are some of the sites we recommend for our visitor

  58. So cool

    The information provided in the article are some of the best available

  59. car games says:

    Websites you should visit

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose

  60. Sites we like

    the time to read or visit the content or sites we have linked to below the

  61. Websites we think you should visit

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  62. Sites we like

    the time to read or visit the content or sites we have linked to below the

  63. Blogs you should be reading

    please visit the sites we follow, including this one, as it represents our picks from the web

  64. Great Content

    we like to honor many other web pages on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  65. Websites you should visit

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose

  66. cash says:

    Great Content

    we like to honor many other internet pages on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  67. Online Article

    Every so often in a while we choose blogs that we read. Listed underneath are the latest sites that we choose

  68. So cool

    The information provided in the article are some of the best available

  69. iforex says:

    Online Article

    Every so often in a while we choose blogs that we read. Listed above are the latest sites that we choose

  70. Blogs you should be reading

    please visit the sites we follow, including this one, as it represents our picks from the web

  71. Sources

    Here are some of the sites we recommend for our visitor

  72. Great Content

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  73. sell gold says:

    Excellent website

    the time to read or visit the content or sites we have linked to below the

  74. Aurelio says:

    Excellent website

    the time to read or visit the content or sites we have linked to below the

  75. Blogs you should be reading

    please visit the sites we follow, including this one, as it represents our picks from the web

  76. Sites we like

    the time to read or visit the content or sites we have linked to below the

  77. Blogs you should be reading

    please visit the sites we follow, including this one, as it represents our picks from the web

  78. Great Content

    we like to honor many other internet pages on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  79. site says:

    Great website

    please visit the sites we follow, including this one, as it represents our picks from the web

  80. Websites we think you should visit

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  81. Sources

    Here are some of the sites we recommend for our visitor

  82. Great Content

    we like to honor many different web sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  83. Websites we think you should visit

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

  84. Check this out

    The information mentioned in the article are some of the best available

  85. deep house says:

    Blogs you should be reading

    please visit the sites we follow, including this one, as it represents our picks from the web

  86. this page says:

    Websites you should visit

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose

  87. Sites we like

    the time to read or visit the content or sites we have linked to below the

  88. love spells says:

    Sources

    Here are some of the sites we recommend for our visitor

  89. Check this out

    The information mentioned in the article are some of the best available

  90. Sources

    Here are some of the sites we recommend for our visitor

  91. Websites you should visit

    Every once in a while we choose blogs that we read. Listed below are the latest sites that we choose

  92. Doctor baby says:

    Cool sites

    Here are some of the sites we recommend for our visitor

  93. SpielAffe says:

    fun games

    Hi there, I found your blog via Google while searching for a related topic, your website came up, it looks good. I’ve bookmarked it in my google bookmarks.

  94. Promo code December 2013

    Despite having three decades of product innovation under their belts, the designers at Burton are still coming up with ideas Promo code December 2013

  95. The site was so nice, I found out about a lot of great things. I like the way you make your blog posts. Keep up the good work and may you gain success in the long run.

  96. Cool sites

    Here are some of the sites we recommend for our visitor

  97. Sources

    Here are some of the sites we recommend for our visitor

  98. Check this out

    The information mentioned in the article are some of the best available

  99. Websites we think you should visit

    we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out

Leave a Reply

You must be logged in to post a comment.