Dan los primeros pasos del test sanguíneo del Alzheimer

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Investigadores de Florida han empleado una gran biblioteca de moléculas artificiales seleccionadas de forma randomizada, los peptoides, para cribar anticuerpos hallados en el torrente sanguíneo de animales o pacientes con enfermedades específicas, como el Alzheimer.

Usando una nueva tecnología que depende de miles de moléculas sintéticas para buscar anticuerpos específicos de patologías, científicos del Instituto de Investigación The Scripps, en Florida, han desarrollado un método potencial para detectar la enfermedad de Alzheimer con un análisis de sangre.

El equipo, coordinado por Thomas Kodadek, ha empleado una gran biblioteca de moléculas artificiales seleccionadas de forma randomizada, conocidas como peptoides, para cribar anticuerpos hallados en el torrente sanguíneo de animales o pacientes con enfermedades específicas y no en controles sanos.

La investigación, que se publica en el último número de Cell, comenzó como una prueba de concepto en la que los autores empezaron con ratones con encefalitis autoinmune experimental, una patología que se asemeja a la esclerosis múltiple en humanos. Mediante el uso de miles de peptoides, los investigadores llegaron a un gran grupo que podrían distinguir muestras de sangre  tomadas de ratones sanos frente a enfermos.

El siguiente reto fue ver si el mismo método podría también emplearse en el caso de la enfermedad de Alzheimer humana. Kodadek describe esto como una elección dudosa. Su método descubrió tres peptoides que parecen discriminar con gran precisión entre las muestras de sangre de individuos sanos y con Alzheimer.

Ahora, el coordinador del estudio ha afirmado que han extendido el test a más pacientes y que parece que se sustenta bien. No obstante, el desarrollo de un análisis clínicamente útil dependerá de más validaciones.

Por otro lado, Kodadek ha advertido que es posible que el test no funcione de forma muy fiable en un grupo de pacientes que representen  etnias diferentes o distintas formas de demencias.

Por ello, los investigadores necesitarán trasladar su tecnología de peptoides a una plataforma simple mejor adaptada a su uso fuera del laboratorio de investigación.

En otras patologías
Además, los autores del trabajo que se publica en Cell planean ahora analizar su método en el contexto de enfermedades como el cáncer de páncreas, donde está claro que un diagnóstico temprano tendría importantes implicaciones en la supervivencia de los pacientes.

Si con esta tecnología se lograran hallar anticuerpos y antígenos naturales, esto ayudaría a desarrollar nuevas vacunas contra el cáncer. “Éste es el esecenario soñado”,  según Kodadek.

Fuente: www.diariomedico.com

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