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Los estudios futuros sobre células madre tendrán que incidir más en el estudio de su genética, debido a que al menos una parte de la reprogramación tumoral está basada en mecanismos epigenéticos.
Esta fue una de las conclusiones que se han podido extraer de la ponencia Reprogramming Hematopoietic Stem Cells into Tumor Cells, a cargo de Carolina Vicente Dueñas, del Centro de Investigación del Cáncer de Salamanca (CIC), en el OncoBIO 2010.
Según ha recalcado a Diario Médico, de momento los estudios son preliminares, pero pueden ser claves a la hora de controlar la expresión de las proteínas anormales en este tipo de células a nivel genético. Este grupo de investigación, que coordina el científico Isidro Sánchez García, ha sido el primero en descubrir la reprogramación tumoral en cáncer, concretamente en tumores hematopoyéticos. Sus hallazgos han sido publicados en varias revistas internacionales especializadas de gran calado como The EMBO Journal o Seminars Cancer Biology.
Junto a Barbacid
Ahora, el grupo está trabajando en colaboración con Mariano Barbacid, del Centro Nacional de Investigaciones Oncológicas, para comprobar si esta reprogramación tumoral también tiene lugar en tumores sólidos como el cáncer de pulmón, entre otros.
El descubrimiento de la reprogramación tumoral supone una propiedad y/o función nueva de algunos oncogenes y ayuda a explicar el fracaso de las terapias usadas en la clínica oncológica, según ha explicado el investigador principal del grupo Isidro Sánchez García. Ha destacado que ayudará a saber la causa por la que los tumores reaparecen tras un tiempo y a qué se debe que algunos inhibidores específicos frente a oncogenes no destruyen todas las células tumorales.
A su juicio este descubrimiento abre la posibilidad de poder destruir la célula tumoral desde un prisma que no se ha considerado hasta ahora. Pero antes de poder aplicarlo “hay que descifrar cuáles son los entresijos de la reprogramación tumoral”.
Vicente Dueñas ha explicado que los esfuerzos de su laboratorio se centran en reprogramar células madre normales mediante la expresión de un oncogén específico asociado a una patología en humanos y ver si son capaces de reprogramarlas en células tumorales. Lo han hecho en diferentes modelos, como el de la leucemia mieloide crónica, patología en la que se sabe que su origen celular es una célula madre. Además, ha destacado que “con nuestros modelos transgénicos somos ahora capaces de reproducir con bastante precisión la enfermedad humana”.
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