Potenciar EphB2 mejora la función cognitiva en EA

Desear la inmortalidad es desear la perpetuación de un gran error

Arthur Schopenhauer

Elevar los niveles neuronales de la proteína EphB2 (receptor 2 de la efrina tipo B) mejora la memoria en un modelo de ratón de enfermedad de Alzheimer, según se desprende de las conclusiones de un estudio que se publica hoy en Nature. Lennart Mucke, del Instituto de Enfermedaes Neurodegenerativas de la Universidad de California, en Estados Unidos, y autor principal, señala que a partir de este punto podrían surgir numerosas dianas nuevas destinadas a mejorar la intervención terapéutica.

Memoria y aprendizaje
En el ensayo llevado a cabo, los ratones modificados genéticamente para disponer de niveles reducidos de la citada proteína muestran déficits funcionales muy similares a los que se observan en pacientes de la enfermedad de Alzheimer. En concreto, oligómeros beta-amiloides se unen al dominio de repetición de la fibronectina de EphB2 y desencadenan su degradación en el proteosoma.

Mucke y su grupo han determinado que los animales sufren de fallos en el proceso de potenciación a largo plazo (la señal eléctrica que potencia el aprendizaje y la memoria queda afectada) y de alteraciones en el funcionamiento de los receptores del glutamato tipo NMDA, que también están relacionados con el aprendizaje y la memoria.

Los investigadores, entre los que también se encuentran científicos del departamento de Neurología de la citada universidad, demuestran cómo los fragmentos de péptidos beta-amiloides, causantes de las placas características del Alzheimer, se unen a EphB2, desencadenando su ruptura.

Varias opciones
Sobre esta base, las conclusiones del trabajo sugieren que los fármacos capaces de elevar los niveles de EphB2 podrían ser útiles para tratar el Alzheimer. Las opciones terapéuticas son diversas, ya que podría tratarse de moléculas que prevengan la unión de los péptidos beta-amiloides con EphB2, que bloqueen su ruptura o que mejoren la capacidad de interacción con los receptores NMDA.
(Nature 2010; DOI: 10. 1038/nature09635).

Fuente: www.diariomedico.com

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