Confirman la importancia de una proteína mutada en la demencia

Leer sin pensar nos hace una mente desordenada. Pensar sin leer nos hace desequilibrados .

Confucio

Científicos de Japón y de la Facultad de Medicina de la Universidad de San Diego, en California (Estados Unidos) han creado un modelo murino que confirma el papel de una proteína mutada llamada beta-sinucleína en la neurodegeneración. El descubrimiento supone un nuevo objetivo a combatir a la hora de desarrollar tratamientos contra enfermedades como el Parkinson o el Alzheimer.

El estudio, publicado en la revista Nature Communications, cuenta como principal autor con Makoto Hashimoto, del Departamento de Química y Metabolismo del Instituto Metropolitano de Neurociencia de Tokio, en Japón. Uno de sus colaboradores, Albert R. La Spada, del Instituto de Medicina Genómica de San Diego, descubrió en 2004 las mutaciones que sufría una familia aquejada de una enfermedad neurológica llamada Demencia con Cuerpos de Lewy (DCL). Este es uno de los tipos más comunes de demencia y combina síntomas del Parkinson y del Alzheimer. Supone un conjunto anormal de proteínas para el que no hay cura ni terapias para detener o paliar su progresión.

En el estudio de 2004 los científicos hallaron que las mutaciones naturales de la Beta-sinucleína en pacientes con DLC eran lo bastante fuertes como para pensar en su patogenia, es decir, que la proteína mutada pudiera ser causada o causante de la enfermedad. No obstante, los resultados no fueron concluyentes.
En la última investigación, se creó un modelo murino transgénico para albergar la mutación de la beta-sinucleína. El ratón acabó sufriendo una enfermedad neurodegenerativa, lo que confirmó el trabajo previo de La Spada.

“El interés de la beta-sinucleína reside en su relación con la alfa-sinucleína, que puede causar Parkinson mediante la mutación o el exceso de la misma”, afirma La Spada. El estudio confirma que ambas provocan la neurodegeneración debido a su estructura y diseño similares.

Fuente:www.diariomedico.com

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