Descubren un gen que vincula la diabetes tipo 2 con el Alzheimer

Lo peor no es cometer un error, sino tratar de justificarlo, en vez de aprovecharlo como aviso providencial de nuestra ligereza o ignorancia.

Santiago Ramón y Cajal

Científicos de la Facultad de Medicina de Mount Sinaí, en Nueva York (Estados Unidos), han descubierto que un gen asociado a la aparición de la diabetes tipo 2 se encuentran niveles más bajos de lo normal en pacientes con Alzheimer. El trabajo se ha publicado en Aging Cell.

Esta investigación podría explicar el vínculo entre la diabetes tipo 2 y el comienzo y desarrollo de la enfermedad de Alzheimer. Los últimos datos revelan que los pacientes con este tipo de diabetes tienen el doble de posibilidades de desarrollar Alzheimer. Sin embargo, los científicos aún no pueden explicarlo.

“La relación entre la diabetes tipo 2 y el Alzheimer ha sido esquiva”, afirma el director de la investigación Giulio Maria Pasinetti, profesor de Neurología y de Psiquiatría en la Facultad de Medicina Mount Sinaí. “Sin embargo, han surgido nuevos datos muy interesantes que ponen de manifiesto que aproximadamente el 60 por ciento de los casos de Alzheimer tienen un vínculo con la diabetes tipo 2”.

Para la investigación, los científicos utilizaron ratones mutados genéticamente que habían desarrollado Alzheimer. El equipo de Pasinetti descubrió que el gen PGC-1, un regulador de la glucosa que en la actualidad se está investigando como posible tratamiento contra la diabetes tipo 2, está en menor cantidad en los pacientes con Alzheimer. Además, comprobaron que el gen PGC-1 promueve la degradación de las enzimas BACE (relacionadas con el procesamiento, y eventualmente con la generación de la proteína beta-amiloide, altamente vinculada al Alzheimer).

“Nuestro estudio es el primero que ha descubierto que el gen PGC-1 es un denominador común entre la diabetes tipo 2 y la enfermedad de Alzheimer”, explica Pasinetti.

Fuente: www.diariomedico.com

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