La ptau en el LCR identifica la agresividad del Alzheimer

Una variación genética que parece predecir cómo progresa el Alzheimer está siendo investigada por un equipo de la Universidad de Washington, en Saint Louis.

Los hallazgos, que se publican hoy en PLoS Genetics, podrán ayudar a determinar la progresión de la demencia tras el diagnóstico de la enfermedad. Estudios previos han visto que la presencia de una forma de la proteína tau (ptau) en el líquido cefalorraquídeo puede ser un indicador de Alzheimer.

Así, analizando una muestra de las variaciones de ADN en 846 pacientes, los autores del estudio, cuyo primer autor es Carlos Cruchaga, han sido capaces de identificar un marcador genético que se asocia a niveles elevados de ptau, que a su vez se relaciona con la progresión rápida de la enfermedad. “Hemos revisado de forma independiente los datos de tres estudios internacionales y en los tres hemos encontrado la misma asociación”.

Los hallazgos genéticos, combinados con la capacidad para medir la ptau en el líquido cefalorraquídeo, pueden significar que la inhibición farmacológica de la acumulación de tau en el LCR pueda prevenir o retrasar los efectos del Alzheimer. Estos datos serán útiles para diseñar ensayos clínicos que ayuden a identificar a los sujetos que tienen más probabilidades de experimentar una rápida evolución y evaluar la respuesta de los fármacos diseñados para retrasar la enfermedad.

Fuente: www.diariomedico.com

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