Un artículo en The Journal of Biological Chemistry propone un nuevo tipo de diana farmacológica que, combinada con un factor neurotrófico, permitiría mejorar la supervivencia de las neuronas estriatales, las que degeneran en la enfermedad de Huntington. El trabajo ha sido dirigido por Sílvia Ginés, profesora agregada de la Universidad de Barcelona (UB), con la participación de Paola Paoletti, estudiante de doctorado, y de Jordi Alberch, catedrático de la UB.
Uno de los candidatos actuales más estudiados como diana terapéutica en Huntington es el factor neurotrófico derivado del cerebro (BDNF), esencial en la supervivencia de las neuronas estriatales, y en esta enfermedad se ve muy disminuido. Sobre un modelo celular in vitro estudiaron si las células que expresan la huntingtina mutada responden bien a la administración de BDNF: “La terapia con BDNF sigue siendo una buena diana de investigación para esta enfermedad, pero muy probablemente requerirá tratamientos combinados para modular diferentes aspectos de la patología de la enfermedad de Huntington”, explica Ginés, que también es investigadora del Idibaps y del CiberNED.
Para poder actuar, el BDNF debe combinarse con un receptor de membrana (TrkB), que también se ve disminuido como consecuencia de la enfermedad. Dicho receptor es el que permite iniciar la señalización de las tres vías implicadas en la supervivencia de las neuronas estriatales. El siguiente paso es encontrar “moduladores para la tercera vía (MAPK/ERK1/2) como posible terapia final, e incluso intentar modular el mismo receptor de membrana para que sea más eficiente en la respuesta”.
Fuente: www.diariomedico.com
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