Describen un gen clave para la proliferación celular en el sistema nervioso

neuronasEl hallazgo abre la posibilidad de frenar la multiplicación indebida de células tumorales de origen neural.

Investigadoras del Consejo Superior de Investigaciones Científicas (CSIC) han descubierto que el gen Sox5 controla la proliferación de las células en el sistema nervioso de vertebrados, lo que abre la posibilidad de alterar los niveles de este gen para frenar la proliferación indebida de células tumorales de origen neural.

Para el trabajo, que publica este mes la revista de la Organización Europea de Biología Molecular, EMBO reports, las investigadoras del Instituto Cajal en Madrid, dependiente del CSIC, han utilizado un modelo clásico de estudio del desarrollo embrionario. En él, han analizado el momento en que los precursores neurales de la médula espinal de los vertebrados dejan de dividirse en nuevas células y comienzan a diferenciarse dando lugar a cada una de las neuronas que conformarán la médula espinal, fase controlada por el gen Sox5.

“Recientemente se ha demostrado que en pacientes con gliomas (en torno al 60% de los tumores cerebrales son de este tipo) la presencia de Sox5 puede ser un marcador de buen pronóstico y que la elevación de Sox5 en células de gliomas humanos en cultivo inhibe la proliferación celular”, explica la investigadora que dirige este trabajo, la doctora Aixa Morales, para quien este descubrimiento “abre una nueva perspectiva en el control de la progresión tumoral”.

Fuente:www.jano.es

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