Unos 150 polimorfismos nucleótidos únicos se asocian a gran longevidad

Mientras que el medio ambiente y la historia familiar son factores que influyen en un envejecimiento saludable, las variantes genéticas también tienen un papel crítico y complejo en la longevidad excepcional, según un estudio coordinado por Paola Sebastiani, de la Universidad de Boston, que se publica hoy en Science.

Su grupo ha identificado las variantes genéticas que pueden predecir una longevidad fuera de lo normal con un 77 por ciento de precisión. Para eso diseñaron un modelo genético único que incluía 150 variantes genéticas, conocidas como polimorfismos nucleótidos únicos, que se emplean para predecir si una persona puede sobrevivir más de 90 años. “Además, nuestro análisis ha identificado 19 huellas genéticas de una logevidad excepcional caracterizada por el 90 por ciento de los sujetos centenarios que participaron en el estudio”.

Los autores del trabajo han especificado que la predicción no es perfecta, pero puede aumentar el conocimiento sobre las variaciones del genoma humano. “Las limitaciones confirman que los factores ambientales también contribuyen en la forma que tiene el hombre de sobrevivir a edades muy avanzadas. Nos queda por entender cómo predisponen estas variantes de forma conjunta a la longevidad”. (Science; DOI: 10.1126/ science.1190532).


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