“El uso de células madre embrionarias, sin futuro en tratamientos en humanos “

La aplicación clínica en tratamientos para humanos de las células madre embrionarias “no tiene futuro, porque su crecimiento es muy difícil de controlar y presentan todavía muchos problemas de compatibilidad con los pacientes”, ha afirmado César Nombela, catedrático de Microbiología de la Universidad Complutense de Madrid y expresidente del Consejo Superior de Investigaciones Científicas (CSIC), en su intervención en un debate organizado por el CSIC sobre las distintas posibilidades que ofrecen las células madre.

El profesor Nombela ha señalado que de los más de 3.000 estudios registrados en el mundo “ni uno sólo se está realizando con células embrionarias; todos son con células madre adultas. Con embrionarias sólo hay alguna iniciativa para recoger líneas celulares de las ya existentes”.

Nombela ha subrayado que “la información que se ha obtenido de ellas es fascinante, pero hay un problema ético de fondo, ya que la investigación debe respetar la vida humana desde el inicio embrionario. En cambio la investigación con células madre del adulto avanza a un ritmo vertiginoso y ya hay numerosas experiencias con células madre hematopoyéticas obtenidas de la medula ósea o del cordón umbilical e, incluso, con células madre obtenidas de la grasa”.

Estos procedimientos son mucho menos traumáticos y, a pesar de que su aplicación en tratamientos es todavía limitada, ya se han obtenido “resultados positivos en la restauración del sistema hematopoyético, en tumores, inmunodeficiencias, procesos inflamatorios intestinales y, además, se empiezan a plantear algunos tratamientos para el sistema nervioso central. Eso sí, estos resultados se han obtenido siempre con células madre adultas, ya que es la vía más inmediata y segura de aplicar y la que debe constituir una gran prioridad para los investigadores de todo el mundo”.

Los nuevos avances
Por otra parte, ha hecho hincapié en la gran novedad que ha surgido con el tratamiento con células iPS. “Suponen una tecnología que permite, por modificación genética, revertir células diferenciadas del adulto a estados pluripotenciales, es decir, estados en las que las células se comporten de un modo parecido a las células de origen embrionario o a las células adultas con más troncalidad”. Según Nombela, “esta tecnología está avanzando, pero hay que ser prudente”.

Fuesnte: www.diariomedico.com

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