Localizados reagrupamientos genéticos en las cinasas RAF en distintos tumores

ESTÁN IMPLICADOS LOS GENES SLC45A3, BRAF, ESRP1 Y RAF1.

Un estudio que se publica hoy en Nature Medicine revela la existencia de reagrupamientos genéticos que implican proteínas específicas en casos de cáncer de próstata, gástrico y melanoma. Las moléculas híbridas que resultan de esta reorganización genética podrían representar nuevas dianas terapéuticas.

Arul Chinnaiyan, de la Universidad de Michican, en Estados Unidos, es el autor principal de la investigación. Junto a su equipo ha descrito nuevas fusiones de factores transcripcionales, uno de los elementos relacionados con el cáncer y que desde hace años supone un desafío para la comunidad investigadora.

Los autores se han valido de técnicas de secuenciación para identificar diferentes tipos de reagrupamientos genéticos y fusiones entre proteínas entre los genes SLC45A3 y BRAF y entre ESRP1 y RAF1. Dicha reorganización genética está directamente relacionada con miembros de la familia de cinasas RAF, proteínas que siempre han estado ligadas al hallazgo de nuevas dianas farmacológicas. Por ello, han estudiado si las células vinculadas a los reagrupamientos genéticos serían susceptibles de responder a determinados tratamientos.

Según apuntan en la publicación, la expresión de las fusiones proteómicas en células de cáncer prostático induce características inherentes al cáncer que permiten una mayor sensibilidad a los inhibidores de cinasas RAF.

Aunque no se producen a menudo, las reorganizaciones genéticas pueden darse en cánceres prostáticos avanzados, al igual que en tumores gástricos y melanomas. Los resultados logrados por el equipo de Chinnaiyan muestran que los inhibidores de RAF podrían ser útiles en el tratamiento de tumores vinculados a fusiones genéticas. Además, demuestran que la secuenciación de genomas tumorales permitirá mejorar la identificación de reordenamientos genéticos en diferentes tipos de cáncer.

Fuente: www.diariomedico.com

48 Responses to “Localizados reagrupamientos genéticos en las cinasas RAF en distintos tumores”

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