El gen ‘DeltaFosB’ es capaz de mediar la resistencia al estrés

ELEVA LOS NIVELES EN EL NÚCLEO ‘ACCUMBENS’ DEL CIRCUITO DE RECOMPENSA

Un equipo del Instituto Nacional de Salud Mental de Estados Unidos ha descubierto un mecanismo que ayuda a explicar la resistencia al estrés, la vulnerabilidad a la depresión y el funcionamiento de los antidepresivos. El trabajo, que se publica hoy en la edición electrónica de Nature Neuroscience, muestra que la reducción de los genes reguladores clave, denominados DeltaFosB, está sobre todo presente en los pacientes con depresión.

Científicos del Instituto Nacional de Salud Mental de Estados Unidos, coordinados por Eric Nestler, del Mount Sinai, en Nueva York, han descubierto un mecanismo que ayuda a explicar la resistencia al estrés, la vulnerabilidad a la depresión y el funcionamiento de los antidepresivos. El hallazgo en el circuito de recompensa de los cerebros de ratones y de humanos ha potenciado un cribado de alta tecnología para moléculas que disparan la acción de un gen regulador clave denominado DeltaFosB. Los resultados se publican hoy en Nature Neuroscience y podrían conducir a fármacos que ayuden a los pacientes con estrés crónico.

“Hallamos que es necesario y suficiente para la resistencia disparar DeltaFosB en el núcleo accumbens del circuito de recompensa. Esto protege a los ratones de desarrollar un síndrome similar a la depresión que sigue al estrés social crónico”, ha explicado Nestler. “Los antidepresivos pueden invertir este síndrome fomentando DeltaFosB. Estos genes están reducidos sobre todo en pacientes con depresión”.

Adicciones
El uso crónico de drogas de abuso -o incluso de recompensas naturales como el exceso de comida, el sexo o el ejercicio- puede inducir gradualmente un incremento de los niveles de este factor de transcripción en el núcleo accumbens. El equipo de Nestler ha mostrado que este aumento de DeltaFosB puede conducir eventualmente a cambios en células que incrementan las respuestas de recompensa a tales estímulos, secuestrando un circuito de recompensa individual.

El nuevo estudio en ratones y cerebros de humanos post-mortem confirma que el mismo circuito de recompensa es corrompido de forma similar en depresión a través de los efectos del estrés en DeltaFosB.

Fuente:Diariomedico.com

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