Una fosfatasa está ligada a la preservación de la integridad neuronal

INPP4A Y GLUTAMATO

Una enzima relacionada con la eliminación de fosfato se vincula directamente con la regulación de procesos neurodegenerativos, según publica hoy en Nature Neuroscience un equipo dirigido por Junko Sakaki, de la Universidad Akita, de Japón.

El inositol polifosfato fosfatasa 4a (INPP4A) protege a las neuronas de la muerte celular provocada por una excesiva activación del receptor del glutamato. Los ratones que carecen de esta enzima sufren apoptosis neuronal en el estriado y experimentan movimientos involuntarios.

La muerte celular excitotóxica ya se había vinculado con el Parkinson y la corea de Huntington. Sakaki cree que esta proteína preserva la vida celular desregulando receptores del glutamato.

Fuente:Diariomedico.com

36 Responses to “Una fosfatasa está ligada a la preservación de la integridad neuronal”

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