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Sólo los sabios más excelentes y los necios más acabados son incomprensibles

Confucio

El Premio Nobel de Medicina Richard Roberts considera excesivas las expectativas que ha suscitado la medicina individualizada porque no reporta grandes beneficios a la industria farmacéutica. Aboga por buscar antibióticos sin depositar toda la confianza en las farmacéuticas.

Richard Roberts ha visitado Santiago de Compostela para dar una conferencia hoy, a las 8 de la tarde, en el Aula Sociocultural de Novacaixagalicia de la capital gallega, dentro del programa ConCiencia de la Universidad compostelana (USC). Su padrino, el catedrático de Medicina Legal de la USC Ángel Carracedo, ha querido resaltar precisamente el descubrimiento que le valió el Nobel: “Es el hallazgo más importante de la historia de la biología de la medicina”. Junto a Phillip A. Sharp, Roberts descubrió los intrones, fragmentos de ADN que están presentes en los genes pero que no codifican información. El científico descubrió también que los genes pueden ser discontinuos, es decir, pueden estar presentes en el ADN en diferentes segmentos separados.

Exhibiendo el discurso independiente y claro que le es propio, ha contestado un sí sin matices cuando DM le ha preguntado si la esperanza que en los últimos años se ha depositado en la medicina farmacológica especialmente dirigida a los genes de cada paciente supera lo que la realidad deparará en el futuro: “Sí, son excesivas las expectativas porque para la industria no es rentable buscar medicamentos para personas concretas, así que se correría el riesgo de que muy pocos se pudieran beneficiar de la medicina individual”.

De todas formas, aboga por profundizar más en la investigación del genoma humano, especialmente en el significado funcional de algunos genes: “Hay que gastar más dinero en este aspecto”. Con respecto a los intrones, ha señalado que algunos tienen función, pueden contener genes o moléculas de ARN, y espera que se avance más en su conocimiento. “No me interesa ser conocido como el descubridor del ADN basura“, ha bromeado.

Su conferencia dentro del programa ConCiencia se titula ¿Por qué me gustan las bacterias? Haciendo gala de la misma sorna inglesa, Roberts ha asegurado que eligió el título antes de que la Escherichia coli se hiciese tristemente famosa y que, pese a ello, mantiene su gusto por las bacterias: “No es fácil saber de dónde vienen este tipo de bacterias; vienen de todas partes, algunas son buenas y otras malas; la vida no es algo sin riesgo”.

Con respecto a la crisis sanitaria generada por la E. coli ha confesado que no puede avanzar ninguna causa específica, pero ha recomendado que se limite el uso de antibióticos en animales destinados al consumo humano, especialmente los sanos: “Mi principal sugerencia es para los granjeros: que no usen tantos antibióticos. Utilizan pequeñas cantidades para mejorar la productividad de sus animales y lo que ocurre es que así se generan resistencias antibióticas de las bacterias y, en consecuencia, los fragmentos de ADN que llevan información resistente a antibióticos se esparcen por todas partes”.

También ha añadido que es esencial que en la agricultura se cumplan las regulaciones aprobadas: “En muchos casos la sorpresa es que no aparezcan más problemas”.

El Nobel de 1993 cree que este tipo de problemas son difíciles de evitar pero que se pueden combatir. A su juicio, un remedio es que los países compartan la información: “Si se esconde la información, el mundo no tiene tiempo de prepararse. Y no se está compartiendo información para afrontar las enfermedades causadas por bacterias y, cuando se hace, ocurre tarde”.

Además de utilizar con precaución los antibióticos existentes, es necesario buscar nuevos y, en este sentido, ha insistido en sus críticas a la industria farmacéutica: “A las grandes compañías farmacéuticas les interesan más los fármacos que los pacientes tengan que usar toda su vida que aquéllos que les puedan curar”.

“Los nuevos antibióticos que salen al mercado vienen de pequeñas compañías biotecnológicas, que tienen una tasa de producción muy baja”, ha destacado Roberts, y ha aconsejado levantar la mirada de las grandes compañías si se quiere lograr una medicina curativa, y apostar por nuevos caminos: “Hay que fomentar la investigación con fondos públicos y dar otros incentivos a la industria privada”.

Fuente:www.diariomedico.com

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