Nanopartículas de cera para realzar la respuesta inmune a los antígenos

copernica-prunifera.jpgEstar preparado es importante, saber esperar lo es aún más, pero aprovechar el momento adecuado es la clave de la vida.

 

 Arthur Schnitzler

La compañía farmacéutica Particle Sciences ha formulado una serie de nanopartículas de cera que, unidas a un antígeno, realzan la inmunogenicidad, elevando la respuesta inmune sistémica y de la mucosa, según el artículo Las nanopartículas de cera de carnauba realzan la fortaleza de las respuestas celulares y humorales sistémicas y de la mucosa frente al antígeno HIV-gp140, que se publica en el último número de la revista Vaccine.

En el estudio se comprueba que mediante la carga acoplada del antígeno con las nanopartículas de cera, la vacunación subcutánea aportaba una respuesta de niveles elevados de IgG específico igual o mayor que con los adyuvantes tradicionales. Además, la vacuna intranasal junto a antígeno acoplado a nanopartículas de cera indujo una respuesta significativa de la mucosa. Por sí solas, las nanopartículas de cera son no inflamatorias.

El trabajo experimental necesario para realizar el proyecto ha sido desarrollado por Mauricio Arias, de la División de Ciencias Clínicas de la Universidad de San Jorge, en Londres.

Según Andrew Loxley, director de Nuevas Tecnologías de Particle Sciences, “mientras aún estamos con experimentos preliminares, los datos con los que contamos son muy esperanzadores y confiamos en que esta aproximación pueda ser explotada para conseguir vacunas más efectivas y asequibles”. Por otro lado, Loxley ha afirmado que “las nanopartículas de cera tienen una estabilidad que facilita su almacenamiento y se pueden producir de forma sencilla y asequible”.

 Fuente:www.diariomedico.com

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